982 Keratinocytes derived TGFβ is not required for immune homeostasis in mouse skin
نویسندگان
چکیده
منابع مشابه
TGFβ signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin.
Dermal lymphatic endothelial cells (LECs) emerge from the dorsolateral region of the cardinal veins within the anterior trunk to form an intricate, branched network of lymphatic vessels during embryogenesis. Multiple growth factors and receptors are required for specification and maintenance of LECs, but the mechanisms coordinating LEC movements and morphogenesis to develop three-dimensional ly...
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Ying-Ping Xu1,2,4,5, Yuling Shi1,2, Zhi-Zhong Cui4, Hong H. Jiang6, Li Li6, Xiao-Fan Wang7, Li Zhou1,2,3, and Qing-Sheng Mi1,2,3 1Henry Ford Immunology Program, Henry Ford Hospital, Detroit, MI 2Department of Dermatology, Henry Ford Hospital, Detroit, MI 3Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 4Department of Preventive Veterinary Medicine, College of Animal Science an...
متن کاملA Method for the Immortalization of Newborn Mouse Skin Keratinocytes
Isolation and culture of mouse primary epidermal keratinocytes is a common technique that allows for easy genetic and environmental manipulation. However, due to their limited lifespan in culture, experiments utilizing primary keratinocytes require large numbers of animals, and are time consuming and expensive. To avoid these issues, we developed a method for the immortalization of primary mous...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.994